International Journal of Advanced Biochemistry Research

Biochem
Journal

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International Journal of Advanced Biochemistry Research

Vol. 2, Issue 1, Part A (2018)

Antitumor activity of Annona muricata L. fruit and leaves in Ehrlich’s ascites carcinoma cell- treated mice

Author(s): Lames M-Othman, Ahmed K-Hassan, Atef E-Abd Elbaky and Mohamed A-Mahmoud
Abstract: Purpose: The main goal of this study was aimed to evaluate the antitumor effect of A. muricata extract of both leaves and fruit in EAC-bearing mice model in comparison with a standard therapeutic agent, cisplatin.
Methods: The antitumor activity of the ethanol extracts of Annona muricata were evaluated against Ehrlich ascites carcinoma (EAC) tumor in mice at dose of 200mg/kg body weight orally. Mice were divided into five groups. Group I: (Normal group) mice were received (0.2 ml Saline), Group II: (Cancer group) 20 mice were intraperitoneally received EAC cells (2×106cells/mouse I.P.), Group III: (EAC + leaves extract) 20 mice were orally treated after 48 hours from injection of EAC cell with a dose of 200mg/kg body weight daily for 9 consecutive days, Group IV: (EAC + fruit extract) mice were orally treated after 48 hours from injection of EAC cell with a dose of 200mg/kg body weight daily for 9 consecutive days, Group V: (EAC+ cisplatin), 20 mice were intraperitoneally treated with cisplatin after 48 hours from injection with EAC at a daily dose of 2 mg/kg body weight for 9 consecutive days. Total experimental period was 11 days, after 24 h from the last dose, 8 mice in each group were anesthetized by diethyl ether and sacrificed for the histopathological examination of Kidney tissue.
Results: Administration of the extracts resulted in that A. muricata has protective role on the management of histopathological changes occurred in cancer induced mice.
Conclusion: The results suggest that the ethanol extract of Annona muricata L. Leaves and fruit showed anticancer effect when compared to the tumor group.
Pages: 21-24  |  498 Views  218 Downloads
How to cite this article:
Lames M-Othman, Ahmed K-Hassan, Atef E-Abd Elbaky and Mohamed A-Mahmoud. Antitumor activity of Annona muricata L. fruit and leaves in Ehrlich’s ascites carcinoma cell- treated mice. International Journal of Advanced Biochemistry Research. 2018; 2(1): 21-24. DOI: 10.33545/26174693.2018.v2.i1a.11
International Journal of Advanced Biochemistry Research